extracellular vesicles impact factor

These tumour cell-derived EVs are carriers of DAMPs such as HMGB1, HSPs, ATP and mitochondrial DNA, which may facilitate immune recognition of the tumour by creating an inflammatory environment. J. Immunol. Extracellular vesicles (EVs) are heterogeneous, phospholipid membrane-enclosed structures. ISEV is pleased to announce that the first Journal Impact Factor (JIF) of its flagship journal, "Journal of Extracellular Vesicles" has been released by Journal Citation Reports, Clarivate Analytics, 2019. Tumour cell-derived EVs carry a set of immunoregulatory molecules by which they mediate immunosuppression. Immunol. However, many questions remain unanswered. 43, 24302440 (2013). Dieud, M. et al. Google Scholar. EMBO J. For example, in patients with melanoma, tumour cells led to systemic suppression of immune functions through exosomal PDL1 (ref.61). Front. Overall, the evolutionary costs related to the immunogenicity of microbial EVs must be counterbalanced by benefits to the microorganism of EV emission68. J. Extracell. Numerous molecules known to participate in immune regulation have been identified on the surface of EVs (Fig. Furthermore, their immunotherapeutic potential has been confirmed in a wide range of experimental disease models, for example in experimental models of asthma, graft-versus-host disease, type 1 diabetes, experimental allergic encephalomyelitis, experimental autoimmune uveitis, acute respiratory distress syndrome and collagen-induced arthritis (recently reviewed elsewhere122). Sci. Brown, L., Wolf, J. M., Prados-Rosales, R. & Casadewall, A. This mechanism may partly explain the immunocompromised status of patients with cancer118. Dynamic regulation of CD24 expression and release of CD24-containing microvesicles in immature B cells in response to CD24 engagement. It remains unclear whether plasmacytoid DC-derived EVs enable antigen presentation by cDCs through a process similar to cross-dressing or through EV uptake and processing for indirect presentation. This effect of mast cell-derived EVs on type 2 innate lymphoid cells has been attributed to the miRNA miR103a-3p, which is enriched in mast cell-derived EVs. 11, 825 (2020). Vesicles 8, 1596668 (2019). The surface glycans of fungal EVs are also PRR ligands, as are the metalloproteinase GP63 and thrombospondin 1 (TSP1) on parasite-derived EVs70. The importance of exosomal PDL1 in tumour immune evasion. Nat. TKP2020-NKA-26. 38, e100249 (2019). An open access journal JEV publishes research into all areas pertaining to the chemistry, biology and applications of extracellular vesicles including exosomes and apoptotic bodies. This mechanism is supported by the observation that, similarly to cross-dressed DCs, bead-bound exosomes also induce increased activation of T cells. 20, 3457 (2019). Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Both cytokines and EVs function in networks and are characterized by pleiotropic, redundant, synergistic or antagonistic functions. Viruses can also bud from the plasma membrane or can be released from MVBs. Extracellular vesicles (EVs) are important players for intercellular communication. Sengupta, V. et al. Cell 184, 49814995.e14 (2021). In mice and in Syrian hamsters, the intranasal administration of a vaccine based on bacterial outer membrane vesicles induced both mucosal and systemic immune responses to SARS-CoV-2 (ref.149). 17-estradiol promotes extracellular vesicle release and - PNAS 59, 20372046 (2018). Int. DC-derived EVs were shown to present the major cat allergen Fel d 1 and to induce allergic responses87. Commun. 40, e108174 (2021). Marino, J. et al. Wieckowski, E. U. et al. Zitvogel, L. et al. More. The roles of extracellular vesicles in the immune system. En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells. Moreover, given that EVs can cross biological barriers, such as the bloodbrain barrier98 or the bloodtestis barrier99, and certain EVs have immunoregulatory properties, they are attractive candidates for the therapy of autoimmune diseases. Extracellular Vesicle | Journal | ScienceDirect.com by Elsevier Beaded apoptopodia release apoptotic vesicles during apoptosis. For example, allergen-carrying pollensomes are naturally released by pollens of olive and ryegrass86. Proc. Of note, soluble mediators of innate immunity also have important EV-related functions. It is decreased by a factor of around 5.74, and the percentage change is -27.05% compared to the preceding year 2020, indicating a falling trend.The impact score (IS), also denoted as the Journal impact score (JIS), of an academic . 2, 282 (2011). Furthermore, the synaptic transfer of vesicles between donor and recipient DCs through a close and sustained cellcell association was implicated in the cross-priming of tumour-specific CD8+ T cells42 (Fig. 22, 1005 (2021). Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. J. Immunol. Eur. Journal of Extracellular Vesicles - Impact Factor, Overall Ranking Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. Ji, P. et al. The release of EVs by microorganisms serves their biological interest, for example, by enabling rapid membrane remodelling, providing decoys for infection by bacteriophages, protecting against virulence factors and facilitating bacterial spread. (2017) Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic . It is important to remember that cells are exposed to extracellular signals resulting from a temporal combination of extracellular soluble mediators, EVs and non-EV nanoparticles. Cell. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress. PLoS One 5, e11469 (2010). Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Nat. Shlomovitz, I. et al. . Blood 138, 26072620 (2021). Interspecies outer membrane vesicles (OMVs) modulate the sensitivity of pathogenic bacteria and pathogenic yeasts to cationic peptides and serum complement. Zhang, H. et al. EV-mediated immune regulation is also implicated in gestational immunology with respect to the maintenance of immune tolerance to the semi-allogeneic fetus. EVs released by activated or stressed cells or by microorganisms may therefore function as autoimmune triggers. RN7SL1-containing EVs derived from these CAR T cells are efficiently taken up by myeloid cells, in which RN7SL1 activates signalling through the pattern recognition receptors retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5). Immunol. In the case of B cell development, immature primary bone marrow B cells were shown to release CD24+ plasma membrane-derived EVs upon antibody-mediated engagement of CD24, and an EV-mediated exchange of CD24 was documented between populations of B cells33. Nat. The 2018 Journal Impact Factor of 11.00 is a significant milestone for JEV. Amphisomes are formed by the fusion of autophagosomes and MVBs. Int. Regulated polarization of tumor-associated macrophages by miR-145 via colorectal cancer-derived extracellular vesicles. Furthermore, EVs should be distinguished from other extracellular nanoparticles such as lipoproteins and the recently discovered exomeres15 and supermeres16. 19, e2103471 (2021). 93, 727734 (2015). Whiteside, T. L. The role of tumor-derived exosomes (TEX) in shaping anti-tumor immune competence. Marar, C., Starich, B. However, for clinical translation of an MSC-EV therapy, scaled manufacturing strategies are required, which is challenging with primary MSCs due to inter- and intra-donor . This is particularly important given that, in the nanoparticle size range, recent research has identified the presence of extracellular non-EV particles. A more efficient form of semi-direct antigen presentation, known as cross-dressing, takes place when EVs attach to (or are possibly recycled to) the surface of dendritic cells (DCs), in which case the DC plasma membrane concentrates a large number of EV-associated peptideMHC complexes for efficient immune synapse formation. We do not discuss the involvement of miRNAs in detail here and, instead, refer readers to a recent review of the topic106. Nat. Nature 542, 367371 (2017). Med. This process may be of particular importance given that donor APC-derived EVs can leave the graft before it is vascularized and thus before donor APCs can enter the systemic circulation. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. We discuss later how this feature of stem cell-derived and progenitor cell-derived EVs is being exploited in EV-based therapeutic approaches. Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. Setz, C. S. et al. Jeppesen, D. K. et al. J. Clin. Rev. Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors. Mast cell-derived EVs are decorated by FcRIIgE complexes92, and their presence in the circulation is characteristic for individuals with atopy. A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants. IgE-activated mast cells secrete EVs that are internalized by IL-33 pre-activated type 2 innate lymphoid cells, leading to the production of IL-5. The Journal of Extracellular Vesicles is a peer-reviewed open-access scientific journal covering research on lipid bilayer -delimited particles known as extracellular vesicles (EVs). Immunol. Gobiewska, J. E., Wardowska, A., Pietrowska, M., Wojakowska, A. These EVs express high levels of perforin and granzyme B as well as CARs, and thus can induce the death of tumour cells expressing their cognate antigen. Indeed, the number of donor-derived exosomes in peripheral blood samples could indicate early rejection with high specificity and sensitivity in a mouse model of heterotopic heart transplantation105. 29, 747754 (2020). The broad term of bacterial extracellular vesicles is increasingly used to refer to all EVs released by bacteria5. 739593. In addition to T cells, DCs are also a target for Treg cell-derived EVs. Contribution of bacterial outer membrane vesicles to innate bacterial defense. Blood 110, 39783984 (2007). Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Cell 57, 974994.e8 (2022). J. Extracell. Whether other EV-associated cytokines can also initiate signalling via an endosomal cytokine signalling platform144 remains to be clarified. Edit I. Buzas. Manning, A. J. Toyofuku, M., Nomura, N. & Eberl, L. Types and origins of bacterial membrane vesicles. Recently, it was reported that stimulation of the B cell receptor (BCR) or CD24 on a mouse B cell lymphoma cell line with anti-IgM or with cross-linking primary and secondary antibodies, respectively, triggered the production of EVs that carried functional BCR and CD24 to recipient B cells34. These EVs stimulate innate immune cells to produce TNF and IL-6, suggesting that probiotic EVs might have use as novel vaccine adjuvants126. Sci. A special type of ectosome, known as ciliary ectosomes, are shed from the plasma membrane of cilia. Rev. TCR, T cell receptor. Immunoregulatory molecules on the surface of extracellular vesicles (EVs), including the immune-checkpoint molecules programmed death ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) and the apoptosis-inducing ligands FASL and TNF-related apoptosis inducing ligand (TRAIL), interact with cognate ligands and receptors expressed by T cells and natural killer (NK) cells to inhibit their activity or induce apoptosis. Mater. The biogenesis of non-EV nanoparticles remains to be explored. The role of extracellular vesicles in the physiological and pathological regulation of the blood-brain barrier. Denzer, K. et al. Rep. 8, 6065 (2018). Biol. Of note, EVs also include vesicles generated by different cell death mechanisms (such as apoptosis, necroptosis or pyroptosis). Rev. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Moreover, EVs in the plasma of individuals with allergic rhinitis carry significantly larger amounts of the house dust mite allergen Der p 1 than healthy controls and plasma EVs from these individuals induce a shift towards a T helper 2 (TH2) cell response88. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Biological properties of extracellular vesicles and their physiological functions. Recent research has identified novel types of neutrophil-derived EV.
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