Effect of test drugs on pentobarbital-induced sleep in Swiss albino mice, *P<0.05, **P<0.01, ***P<0.001 when compared to control group, #P<0.05 when compared to Jatamansi treated group (One-way ANOVA followed by Tukeys Post hoc test), Data: MeanSEM. The large lipid content of myelin sheaths and the high rate of brain oxidative metabolism coupled with the low antioxidant defenses make the brain highly vulnerable to free radical damage [5, 6]. The https:// ensures that you are connecting to the Antioxidant Activity of Essential Oil and Extracts of Valeriana minutes and filter it. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities of the extracts were investigated according to a previously reported method [10] with minor modifications. Side effects of treatment with benzodiazepines. The fibres present on the was an important plant used to process the traditional Chinese herbal medicines "gansong". Anonymous. According to Ayurveda, Vata governs all the movement and actions of the body and nervous system respectively. A review on pharmacognostic and phytochemical study of a plant Nardostachys Jatamansi.The pharma innovation journal.2017;6(7): 936-941. [19] Each rat was placed in the arena for 10 min and activity was observed. National Library of Medicine Orient J Chem 2016;32(2). The Ayurvedic Pharmacopeia of India, Part I, Vol. length and having elongated and cylindrical shape. Standard control (diazepam) decreased horizontal activity and total freezing time significantly compared to both groups (P < 0.001); whereas vertical activity was also decreased compared to NC (P < 0.001) and test drug (P < 0.01) groups [Table 2 and Figure Figure1a1a--cc]. Accessibility Available from: http://www.orientjchem.org/?p=15336. Valeriana jatamansi - an overview | ScienceDirect Topics Most experimental studies have been conducted on various extracts, essential oils, or isolated components from Jatamansi. Similarly the spectrophotometrically measured phosphomolybdenum complex was also strongly correlated with total phenolics content of these extracts (N. jatamansi, r = 0.9909; S. vaginatum, r = 0.9897). Antioxidant effect on free DPPH radicals and total antioxidant capacity. Three weeks after the 6-OHDA injection, the rats were tested for neurobehavioral activity and were sacrificed after 6 weeks for the estimation of lipid peroxidation, reduced glutathione content. Jatamansi Tablet - 1-2 tablets twice a day. All chemicals and solvents were purchased from Merck Chemicals (Mumbai, India). Results depict that 1200 mg/kg dose had significant antihyperglycemic effects as compared to disease model rats. Nardostachys jatamansi (D.Don) DC.: An invaluable and constantly The oil possess antiarrhythmic Abana, Rumalaya gel, Mentat, Anxocare (Himalaya Drug Company), and 24.5) possesses a significant antistress activity which might be because of its cancer prevention action and it is considered by estimating the free radical searching movement.Accompanied with the way of life alterations and psychotherapy is sheltered, it provides an effective solution against hypertension in all age bunches. It acts as a brain tonic and helps to improve memory and brain functions by preventing cell damage due to its antioxidant property. ; Dipti, S.T. This study showed no toxicity effect even at 3000 mg/kg dose. o.] MacGregor DG, Higgins MJ, Jones PA, et al. (a) Standard mixture (1-protocatechuic acid, 2-chlorogenic acid, 3-syringic acid, 4-ferulic acid); (b) N. Jatamansi methanolic extract; (c) S. vaginatum methanolilc extract. Indian Medicinal Plants:An Illustrated Dictionary Indian Medicinal Plants. Briefly, 0.5mL of deionized water and 0.125mL of different extracts of known dilution (1mg/mL) were added to reaction vial. . Nardostachys jatamansi - Wikipedia Flowers are slightly blue or pink in dense cymes. This site needs JavaScript to work properly. It is stimulant in small doses and also useful in Gu RR, Meng XH, Zhang Y, Xu HY, Zhan L, Gao ZB, Yang JL, Zheng YM. As shown in Figure 1, N. jatamansi extract strongly scavenged DPPH radicals with the IC50 being 52g/mL as compared to 165g/mL for S. vaginatum. Nardostachys jatamansi DC is a small perennial, rhizomatous herb which grows in steep, moist, rocky, undisturbed grassy slopes of India, Nepal, China and Bhutan from 2300 m to 6000 m above sea level. The control group was treated with water, the standard group with diazepam and the test drug with powder of N. Jatamansi rhizome. Observations were made before and at every hour after drug administration for the first 4 h and then at 24 and 48 h. A study was conducted to evaluate the effect of the drug on spontaneous locomotor activity of Charles Foster rats as grouping mentioned in gross behavior test. Ttraditionally the plants have been used from many years for nervous headache, excitement, menopausal symptoms, flatulence, epilepsy and intestinal colic. It is also called spikenard, nard, nardin, or muskroot. [12] The active principle, jatamansone is reported to have tranquilizing, antiemetic, sleep-regulating, and anticonvulsant activities. The study was conducted by using 200 mg/kg, 800 mg/kg and 1200 mg/kg dose for 10 days. Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Animals were fasted overnight before the experiment. in random forms. ; Talera, D.S. It is also . Ethanolic extract of the roots of N. jatamansi was studied for its anticonvulsant activity. ; Ahmad, A.S.; Islam, F.; Protective effect of. Diazepam exerted a significant effect by reducing latency of sleep and increasing total sleep duration in mice when compared to the control group (P < 0.001) [Table 4 and Figure Figure3a3a and andbb]. The activities of glutathione-transferase, glutathione reductase, and catalase, quantification of catecholamine, dopaminergic D2 receptor binding and tyrosine hydroxylase expression. Then, 1.25mL of 7% sodium carbonate solution was added to each reaction vial and the mixture was diluted to 3mL with deionized water. In other study it was observed that effective dose for antihyperglycemic activity of N. jatamansi is 500 mg/kg in diabetic rats. N. jatamansi has many properties with minimum animal studies which provide the researchers a platform to do research on those activities to scientifically validate the finding and serve the humanity. Epub 2020 Feb 23. eCollection 2022. [20], Swiss albino mice were used to evaluate the efficacy of the drug on prolongation of pentobarbitone-induced sleeping time. 1. The animals showed significant changes in the antioxidant enzymes [superoxide dismutase, glutathione peroxidase catalase and glutathione-S-transferase] and lipid peroxidation levels. Tan D, Manchester LC, Reiter RJ, Qi W, Kim SJ, El Sokkary GH. Restraint of rats on metallic chambers for 4 h at 4C was followed by sacrifice and assessment of stress-induced alterations in biochemical parameters, incidence and severity of ulcers. Corresponding author email:hemantdhongade@gmail.com, DOI : http://dx.doi.org/10.13005/ojc/320211. government site. Jatamansi has been traditionally used in treatment of wide range of disorders, which include digestive system, circulatory system, nervous system, respiratory system, urinary system, reproductive system and skin diseases. 2013/14/6104). [9] It is used as a substitute for valerian and as an ingredient of many Ayurvedic drug formulations such as Mamsyadi Total phenolic content and major phenolic acids identified in methanolic extract of N. jatamansi and S. vaginatum. Jagetia, G.C. The total antioxidant capacity of the N. jatamansi and S. vaginatum extracts was found to be 151 and 143mol ascorbic acid equivalent/g, respectively (Table 2). The percent growth inhibition was found to be 71% against IMR-32 and 85% against SK-N-SH at 100 g/ml respectively. HPLC analyses were performed on a liquid chromatography system consisting of Waters (Milford, MA, USA) model 515 pumps and equipped with an online degasser, a Waters PCM (Pump Control Module), a Rheodyne 7725 injection valve furnished with a 20L loop, a Waters 2996 photodiode array detector (PDA), and Waters Empower software. Wolfman C, Viola H, Marder M, Wasowski C, Ardenghi P, Izquierdo I, et al. This finding suggests that N. jatamansi has dose dependent antidepressant activity and can also be used in patients suffering from depression due to sleep disturbances [14]. Accessibility Coumarins of the petroleum ether extract. sharing sensitive information, make sure youre on a federal Doxorubicin at the dose of 15 mg/kg, i.p. ; Pragnesh, V.P. Membership Form of Researchers Society of Chemical Sciences The Ayurvedic Pharmacopoeia Of India.Part 1 Volume 1. Benefits of Jatamansi. sharing sensitive information, make sure youre on a federal Orient J Chem 2016;32(2). Natural products (NPs) were a rich source of diverse bioactive molecules. NC: Normal control group (water), J: Jatamansi group, DM: Diazepam group, SEM: Standard error of mean, CNS: Central nervous system. Lesioning was followed by an increased lipid peroxidation and significant depletion of reduced glutathione content in the substantia nigra which was prevented with N. jatamansi pre-treatment [31]. Epub 2021 Jul 30. It reduced the horizontal activity significantly (P < 0.001) in the open field apparatus. This important traditional drug is also used to treat epilepsy, hysteria, syncope, convulsions, and mental weakness. Ethnopharmacological relevance: libitum. S. vaginatum roots are also used as a nervine sedative and considered useful in hysteria. A new benzodiazepine pharmacology. Some well-known antioxidant polyphenolics, namely, chlorogenic acid, ferulic acid, protocatechuic acid, syringic acid, rutin and quercetin, were analyzed. The hepatoprotective activity was shown by the normalization of various serum enzymes elevated in response to thioacetamide-induced liver damage [13]. Federal government websites often end in .gov or .mil. and scopolamine 0.4 mg/kg i.p. epilepsy, hysteria, and palpitation of heart. ; Kabeer, H.; Diwakar, G. Vinutha, J.P.; Acetyl cholinesterase inhibitory activity of methanolic and successive water extracts of. Essential oils and the component jatamansone have shown such activities experimentally. Various other sesquiterpenes known are nardostachone, dihydrojatamansin, jatamansic acid [7], jatamansinone, oroseolol, oroselone, seselin, nardostachyin, nardosinone, spirojatamol [8], jatamol A and B [9], calarenol [10], seychellene, seychelane, coumarin: xanthogalin [11]. Jatamansi Oil - 2-5 drops of Jatamansi oil or as per your requirement. Nardostachys jatamansi (D.Don) DC. examine under UV light. 2 > 0.98) (Figure 2). DPPH radicals react with suitable reducing agents losing colur stoichinometrically with the number of electrons consumed which is measured spectrophotometrically at 517nm. Folin-Ciocalteu reagent (0.125mL) was added to the solutions and allowed to react for 6min. Medicinal properties of, Bose BC, Gupta SS, Vijayvarigiya R, Saifi AQ, Bhatnager JN. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy effort. However, the test drug did not increase the number of rearing and total freezing time significantly, indicating only mild grade of sedative activity in Jatamansi. Biological cleanup discovered for certain 'forever chemicals' Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The rhizomes are dark grey in colour and are crowned with Clipboard, Search History, and several other advanced features are temporarily unavailable. Consequences of sleep deprivation. Gotumukkala, V.K. 2020 May 23;254:112686. doi: 10.1016/j.jep.2020.112686. Not enough scientific evidence is available on the use of Jatamansi during pregnancy. Nakoti SS, Juyal D, Josh AK. The DPPH radical scavenging activities of the methanolic extracts of N. jatamansi and S. vaginatum are given in Table 2. Orient J Chem 2016;32(2), Sahu R, Dhongade H. J, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. Medicinal Properties of Nardostachys jatamansi (A Review). Zinzius, J.; Jatamansin- a new therapeutic agent in venous stasis and related diseases. It has been reported to exhibit antidepressant, anticonvulsant and antiarrhythmic activities as well as to possess antioxidant and lipid peroxidation activities [1, 2]. N. jatamansi is an important medicinal plant mentioned in Ayurveda and Unani system used for treatment of various diseases. International union of pharmacology. FOIA Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy. Guo Y, Yin T, Wang X, Zhang F, Pan G, Lv H, Wang X, Owoicho Orgah J, Zhu Y, Wu H. J Ethnopharmacol. Jatamansi is useful to manage the symptoms of anxiety. On the rotarod test, Jatamansi did not show a significant decrease in latency of fall off time after 1 h and 3 h compared to the control group on rotarod performance. Mishra, D.; Chaturvedi, R.V. Not enough scientific evidence is available on the use of Jatamansi during breastfeeding. Air-dried (4050C) roots (50g each) were powdered and extracted with warm methanol (3 100mL) by stirring on a magnetic stirrer for 30min each time. 2022 Sep 30;11(10):1962. doi: 10.3390/antiox11101962. On day 21, 2 l of 6-OHDA [12 g in 0.01% in ascorbic acid-saline] was infused into the right striatum, while the sham-operated group received 2 l of vehicle. Careers, Unable to load your collection due to an error. ; Anticonvulsant and neurotoxicity profile of, Subashini, R.; Yogeeta, S.; Gnanapragasam, A.; Devaki, T.; Protective effect of. Phytochemistry and pharmacology of the genus Drypetes: A review. resin, sugar, starch and bitter principle, an alcohol and its isovaleric ester. [18] The procedure involves assigning scores on 0-3 point scale as per the average intensity of the phenomenon observed. Other limitations of different studies were the use of out-dated techniques for phytochemical profiling, absence of toxicology studies using animal models and clinical trials using human subjects. The effect of ethanol extract of N. jatamansi was studied on swiss albino mice exposed to 6Gy in whole body electron beam radiation (EBR). ; Tripathi, S.C.; The fungi toxic effect of the essential of the herb, Ambekar, D.H.T. Epub 2016 Jun 25. We have identified and discussed ambiguities and confusions about the plant's nomenclature and geographical distribution, and highlighted various studies that failed to discuss this issue. Dasmularishta, Mahamarichadi tail (Dabur). ; Balasaheb, D.S. Gupta RC, Milatovic D, Zivin M, Dettbarn WD. Diabetic study was also confirmed by using STZ injection [27]. . N. jatamansi, native to the Alpine Himalayas, is a critically endangered, rhizome-bearing plant that grows best at high altitudes (3,000 to 5,000 m). Our study aims to show the challenges and opportunities of harnessing the untapped pharmaceutical resources of N. jatamansi. It has been observed that compounds with antioxidant properties (superoxide dismutase (SOD) mimetics, vitamin C, spin traps, and melatonin) prevent seizure-induced pathology [1216]. Animals were divided into 3 groups (per model) having six animals in each group. Orze-Gryglewska J. However, extract of N. jatamansi was found to have no significant activity against pentylenetetrazole (PTZ) seizures; it was effective in maximum electric shock model (MES) and increased the seizures threshold [29, 30]. The site is secure. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, et al. SEM: Standard error of mean, Effect of test drugs on Rotarod performance of albino mice. Jatamansi Powder - - teaspoon twice a day. (a) Number of block crossed. Bookshelf All medicines are dispensed in compliance with the Drugs and Cosmetics Act, 1940 and Drugs and Cosmetics Rules, 1945. Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW. [4,5] Benzodiazepines, the most commonly used medications for sleep disorders, are accompanied by side effects such as drug dependence, drowsiness, lethargy, fatigue, amnesia and cognitive impairment. The roots and rhizomes of Nardostachys jatamansi have been used to treat hysteria, syncope epilepsy, and mental weakness. De novo transcriptome analysis of the critically endangered - Nature Mohler H, Fritschy JM, Rudolph U. P value 0.05 was considered statistically significant. Another aim is to explore the possibilities of translating ethnobotanical information into health benefit applications. Please enable it to take advantage of the complete set of features! Enjoy free home sample collection, view reports online and consult a doctor online for free. The scavenging activity was calculated using the formula of scavenging activity (%) = [(A517 of controlA517 of sample)/A517 of control] 100. D./IAEC/13/2013/03) following the guideline formulated by Committee for the Purpose of Control and Supervision of Experiments on Animals, India. Therapeutic evaluation: N. jatamansi (Fig. Nardostachys jatamansi is a flowering plant of the valerian family that grows in the Himalayas. CNKI Scholar (China National Knowledge Infrastructure). (Mean standard error of the mean; *P < 0.05, **P < 0.01, ***P < 0.001 compared to control; #P < 0.05 compared to Jatamansi-treated group), NC: Normal Control, J: Jatamansi, SC: Standard Control. jatamansi contained only benzoic acid derivatives (protocatechuic acid and syringic acid) while hydroxycinnamic acid derivatives (chlorogenic acid and ferulic acid) were present only in the methanolic extract of S. vaginatum. [25] Jatamansone exerted a tranquilizing effect in mice and monkeys[13] and a significant reduction in hyperactivity and improvement in restlessness and aggressiveness on hyperkinetic children similar to amphetamine. [3] Chronic sleep disorders lead to several health consequences such as poor memorizing, emotional instabilities, mental health disorders, changes in the immune response, and increased risk and severity of long-term diseases or conditions, such as high blood pressure, heart disease. Bethesda, MD 20894, Web Policies Ascorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus. Antidiabetic study was further confirmed [26] in which ethanolic extract was used to validate the traditional use of N. jatamansi in hyperglycemia. Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Chatterjee B, Basak U, Dutta J, Banerji A, Prange NT. Frantseva MV, Perez Velazquez JL, Tsoraklidis G, et al. Nardostachys jatamansi DC. is a high altitude plant, growing in the Himalayan foothills. The rhizomes are 2.5 to 7.5 cm in Copyright 2019 Elsevier B.V. All rights reserved. [8] The Ayurvedic Pharmacopoeia of India recommends its rhizomes in skin diseases, cellulitis, disturbed mental state and insomnia. This study aimed to determine central nervous system (CNS) depressant activity of Jatamansi (N. jatamansi) rhizome on experimental animals. No, in fact, Jatamansi helps to improve digestion because of its Laghu (light) property. they are reddish-brown in colour. A substantial amount of high-value biological active compounds . Thus therapies aimed at reducing oxidative stress may ameliorate tissue damage and favorably alter the clinical course. ; Sethu kumar Kamath M.; The evaluation of the radioprotective effect of Triohala in the mice exposed to gama-radiation. [21] The albino mice of either sex were divided into three groups each consisting of six mice as mentioned in Rotarod performance. [10] Sesquiterpenes and coumarins are major active principles in the herb. ; Baliga,M.S. Mahesh M.G. Purnima, Bhatt M, Kothiyal P. A review article on phytochemistry and pharmacological profiles of Nardostachys jatamansi DC-medicinal herb.Journal of Pharmacognosy and Phytochemistry 2015; 3(5): 102-106. The site is secure. The dried rhizome was powdered, sieved through 120 no sieve and stored in an airtight container. The roots of S. vaginatum have yielded several coumarins, namely selinidin, selinone, angelisin, anomalin, isopteryxin, orosenol, lomantin, and vaginidin. Most anti-tumor agents were built on natural scaffolds. Federal government websites often end in .gov or .mil. Reduction in locomotor activity may lead to soothing and sedation as a result of reduced excitability of the CNS. Oxidative injury may play a role in the initiation and progression of epilepsy. ; Chauhan, N.S. ; Kadam,V.J and Kamble, S.S.; Herbal Anxiolyte. Ascorbic acid was used as the standard, and the total antioxidant capacity was expressed as equivalents of ascorbic acid. [27] Thus, earlier studies indicate isolated compounds or extracts exert highly significant sedative activity while data of this study indicates crude form of drug administered in recommended dose produced comparatively mild CNS depressant activity. [9] Animal dose was converted by extrapolating the human dose to animal dose based on the body surface area ratio. Studies on the chemical constituents of N. jatamansi. Careers, Unable to load your collection due to an error. Effect of test drugs on albino rats in open field test, ***P<0.001, when compare to control group; ##P<0.01, ###P<0.001, when compare to Jatamansi treated group (One-way ANOVA followed by Tukeys Post hoc test), Data: MeanSEM. Antioxidants (Basel). Effect of test drugs on rotarod performance of Swiss albino mice, **P<0.01, ***P<0.001, when compare to control group, #P<0.05, ###P<0.001, when compare to Jatamansi treated group (One-wayAnova followed by Tukeys Post hoc test), Data: MeanSEM. Seshadri TR, Sood MS, Handa KL, Vishwapaul Chemical components of the roots of selinum vaginatum-1. The hydro-alcoholic extract was used on wistar albino normal rats, glucose loaded and alloxan induced diabetes. Zheng YD, Ma LM, Lu JJ, Chai T, Naghavi MR, Ma JY, Sang CY, Yang JL. oriented biodiversity conserva tion and biological monitoring at community level, and the community knew that burning practices also impacted the N. jatamansi lev els (Subedi et al . Parkinson disease model was induced in one study by using 6-OHDA injection in wistar rats and was observed that the drug produced a marked decrease in biogenic amine and increase in D2 receptors [28]. Ghaisas, M.M. Hence, there was an urgent need to develop . The N. jatamansi increases the biogenic amines and inhibitory neurotransmitters in the brain. Caprifoliaceae; Critically endangered; Himalayas; Jatamansi; Nootropic; Spikenard. The methanolic extracts of the roots of N. jatamansi contained 39.54mg GAE g1 which was nearly 1.7 times the TPC of the methanolic extract of the roots of S. vaginatum (22.74mg GAE g1) (Table 1). It also exhibits cardio protective activity and used in the treatment of neural diseases. Jatamansi (Nardostachys jatamansi DC.) As a library, NLM provides access to scientific literature. Secondly, both plants exhibited significant variation in their TPC and antioxidant properties. The aqueous and methanolic extracts of rhizomes possess anti-inflammatory activity. Evaluation of drug activities. 8600 Rockville Pike Jatamansi Uses, Benefits & Dosage - Drugs.com Herbal Database [24] Anxiolytic herbs may potentially alleviate psychiatric disorders with minimal adverse effects. HPLC profile of phenolic acids. jatamansi DC. Lifestyle . Jatamansi, also known as tapaswani in Ayurveda, is a perennial, dwarf, hairy, herbaceous and endangered plant species. Would you like email updates of new search results? The Illumina GA IIx sequencing platform was used for de novo transcriptome of N. jatamansi at flowering stage. Molecules. HHS Vulnerability Disclosure, Help (Valerianaceae) and Selinum vaginatum C.B. Conclusions: diabetes, aging, heart problem, cancer and neurodegenerative disorders. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies. Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders. The animals were obtained from the animal house attached to the institute. ; Antibacterial potential of Some Ayurvedic Preparation to Control Bacterial enteric Infection, Ishrat,T. However it significantly [P<0.01] improves the locomotors activity in case of sleep deprivation which is comparable to normal control. Choi BH. Stanilova,S.A. Your privacy is guaranteed. So it is advisable to avoid Jatamansi or use only under medical supervision during pregnancy. Bethesda, MD 20894, Web Policies Rucker, G.; Paknikar, S.K. Molecules | Free Full-Text | Potential Anti-Tumor Activity of The authors do not have any conflict of interests in this paper. The results confirmed hair growth promotion activities of this plant. Free radical scavenging activity of curcuminoids. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice. The increased susceptibility of the brain to oxidative damage and experimental and clinical data suggests a putative role of oxidative stress in the pathophysiology of certain seizure types. ; Agarwal, A.K. The dose response studies of phenytoin alone and in combination with N. jatamansi extract in the serum levels of phenytoin clearly demonstrated the synergistic action of both the drugs [15]. It is considered endangered due to overharvesting for folk medicine, overgrazing, loss of habitats, and forest degradation. A multi-dimensional observation procedure and the study of pharmacological interactions. In order to determine the phenolic acid composition of N. jatamansi and S. vaginatum, their methanolic extracts were subjected to HPLC analysis under the conditions described above. potential sources of sesquiterpenes of common and lesser . A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys. Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Anxiety is mainly due to Vata imbalance. ; Chakravarti, K.K. Nardostachys jatamansi DC. Add 2 g of powder to 5 ml of 80% alcohol and shake for ten Biological Source Jatamansi consists of dried rhizomes of Nardostachys jatamansi D.C., belonging to family Valerianaceae. The HPLC studies showed that out of the compounds analysed, only the phenolic acids (chlorogenic acid, ferulic acid, protocatechuic acid, and syringic acid) were found to be present either in N. jatamansi or S. vaginatum. The plant is critically endangered and found in the alpine and sub-alpine regions of the Himalayas. The previous report suggested that ethanolic extract of Jatamansi significantly altered locomotor activity.
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